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Open-source CAD for paper microfluidics

Open-source CAD for paper microfluidics

autopadResearchers from the Mace lab at Tufts University recently published an article in Scientific Reports highlighting their new open-source CAD software that is tailored for the design of paper microfluidic devices.  The software works across all OS platforms, appears fairly straightforward and user-friendly, and likely capable of covering most of the normal aspects of geometrical design for channel networks, based on examples presented.

The software is provided by the authors gratis in a laudable effort to reduce the costs associated with chip design, especially for resource-constrained environments such as schools and labs in developing countries.  The price for subscription or purchase of industry-standard CAD software can be prohibitive, easily reaching tens of thousands of dollars, and scaling with the number of users, etc.  Removing the cost of design SW breaks down a significant cost barrier to innovation for paper microfluidics, a technology that otherwise boasts very economical costs for consumable materials (paper) and fabrication (wax printing with commercially available printers).

Nanofluidic DNA sieving device from IBM

Nanofluidic DNA sieving device from IBM

nf-dna-reptationFascinating research from the Qinghuang Lin lab at IBM Research in NY, published in Nature Communications and highlighted in Cytofluidix, shows an elaborate but potentially mass-producible microfluidic and nanofluidic lab-on-a-chip device that draws DNA molecules through arrays of nanometre-sized pillars.  The DNA reptation in these structure stretches the molecules out, as in gel-based electrophoretic separations of DNA, and may enable identification of biomarkers that indicate diseases.  The Cytofluidix summary page shows an engaging video of DNA migration through the pillar array.

The research team had to overcome sizable challenges associated with the nanofabrication of the different structures that act as the DNA sieving medium.  Researchers used a sacrificial silicon layer for the nanofluidic channels, and were able to overcome diffusion-limitted etching constraints by using temporary venting holes to accelerate the etching by 2 orders of magnitude.  This process improvement may be the key to making the device a manufacturable product instead of a clever academic exercise.